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US 6,635,647 B2Granted
Decahydro-isoquinolines
AssigneeNovartis AG
InventorThomas J. Troxler
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of formula (I) wherein A, B and R are as defined herein and the preparation thereof. The compounds of formula (I) are useful as somatostatin antagonists.
Claims5
A compound of formula I
- wherein R is hydrogen or (C1-4)alkyl and A and B, independently, are groups of formula (a), (b), (c), (d) or (e)
- wherein
- X, X1 and X2, independently, are —CR1═ or —N═
- Y is —O—, —S—, —CH═CH— or —NH—
- R1 and R′1, independently, are hydrogen, (C1-4)alkyl or (C1-4)alkoxy,
- R2 is hydrogen, (C1-4)alkyl, (C1-4)alkoxy, (C1-4)alkoxycarbonyl) or halogen, and
- R3 and R4, independently, are halogen, nitro, cyano, trifluoromethyl, (C1-4)alkyl, (C1-4) alkoxy, (C1-4)alkoxycarbonyl or (C1-4)alkanoyl,
- in free base or acid addition salt form.
5 more elements
[4-(3,4-Difluoro-phenyl)-piperazin-1-yl]-{(4S,4aS,8aR)-2-[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydro-isoquinolin-4-yl}-methanone in free base or acid addition salt form.
Dependencies are inferred from the claim text.