2,5,-diazabicyclo[2.2.1]heptane derivatives, their preparation and therapeutic uses

A compound of formula (I)

• in which
• one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C—R3 and the third represents a nitrogen atom or a group of formula C—R4,
• R3 and R4 represent, independently of each other, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxyl, (C1-C6)alkyl or (C1-C6)alkoxy group,
• R1 and R2 represent, independently of each other, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxyl, (C1-C6)alkyl or (C1-C6)alkoxy group, or a phenyl group optionally substituted with one or two halogen atoms, with one or two trifluoromethyl groups, with a cyano group, with a nitro group, with a hydroxyl group, with a (C1-C6)alkyl group, with one or two (C1-C6)alkoxy groups, with a methylenedioxy group, with an acetyl group, with a trifluoromethoxy group or with a methylthio group,
• R represents a hydrogen atom or a (C1-C6)alkyl group,
• with the exclusion of the compounds of formula (I) in which
• (a) Y and Z each represent a nitrogen atom,
• (b) X and Z represent a nitrogen atom, Y represents a group CH, R and R2 are hydrogen and R1 is fluorine,
• (c) X represents a nitrogen atom, Z represents a group C(OCH3), Y represents a group CH, and R, R1 and R2 are hydrogen, or
• (d) X represents a nitrogen atom, Z represents a group CH, Y represents a group CCl, and R, R1 and R2 are hydrogen
• in base form or in the form of an addition salt with an acid.