Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives

A compound of formula (I)

• a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid or base addition salt thereof, wherein R1 and R2 taken together form a bivalent radical of formula
• —O—CH2—O— (a-1),
• —O—CH2—CH2— (a-2),
• —O—CH2—CH2—O— (a-3),
• —O—CH2—CH2—CH2— (a-4),
• —O—CH2—CH2—CH2—O— (a-5),
• —O—CH2—CH2—CH2—CH2— (a-6),
• wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl,
• R3 is hydrogen or halo;
• R4 is hydrogen or C1-6alkyl;
• R5 is hydrogen or C1-6alkyl;
• L is C3-6cycloalkyl, C5-6cycloalkanone, or C2-6alkenyl,
• Or L is a radical of formula
• —Alk—R6 (b-1),
• —Alk—X—R7 (b-2),
• —Alk—Y—C(═O)—R9 (b-3), or
• —Alk—Y—C(═O)—NR11R12 (b-4),
• wherein each Alk is C1-12alkanediyl;
• and
• R6 is hydrogen, hydroxy, cyano, C16alkylsulfonylamino, C3-6cycloalkyl, C56cycloalkanone, or Het1;
• R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or Het2;
• X is O,S, SO2 or NR8;
• said R8 being hydrogen or C1-6alkyl;
• R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy;
• Y is NR10 or a direct bond;
• said R10 being hydrogen or C1-6alkyl;
• R11 and R12 each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11 and R12 combined with the nitrogen atom bearing R11 and R12 may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C1-6alkyl, amino or mono or di(C1-6alkyl)amino, or said R11 and R12 combined with the nitrogen bearing R11 and R12 may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C16alkyl;
• and Het1 and Het2 each independently are selected from furan;
• furan substituted with C1-6alkyl or halo;
• tetrahydrofuran a tetrahydrofuran substituted with C1-6alkyl;
• a dioxolane:
• a dioxolane substituted with C1-6alkyl a dioxane;
• a dioxane substituted with C1-6alkyl;
• tetrahydropyran;
• a tetrahydropyran substituted with C1-6alkyl;
• pyrrolidinyl;
• pyrrolidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, or C1-6alkyl;
• pyridinyl;
• pyridinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C1-6alkyl;
• pyriniidinyl pyrimidinyl substituted with one or two substituents each indepentently selected from halo, hydroxy, cyano, C1-6alkyl, C1-6alkyloxy, amino and mono and di(C1-6alkyl)amino;
• pyridazinyl;
• pyridazinyl substituted with one or two substituents each independently selected from hydroxy, C1-6alkyloxy, C1-6alkyl or halo;
• pyrazinyl;
• pyrazinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C1-6alkyl, C1-6alkyloxy, amino, mono- and di(C1-6alkyl)amino and C1-6alkyloxycarbonyl
• Het1 can also bearadical of formula
• Het1 and Het2 each independently can also be selected from the radicals of formula
• R13 and R14 each independently are hydrogen or C1-4 alkyl;
• and
• wherein the —OR4 radical is situated at the 4-position of the central piperidine moiety.