Substituted pyrazoles

A compound of formula (I):

• wherein:
• the dashed line adjacent C—R6 is absent or an sp2 bond;
• Y is nitrogen or R20C;
• Z is nitrogen or R21C;
• T is nitrogen or R2C;
• S is nitrogen or R3C;
• provided that one of S, T, Y, and Z is nitrogen;
• and further provided that one of S, T, Y, and Z can be ═N+—O− with the remaining three not being nitrogen;
• R20 is selected from hydrogen, halogen, C1-5alkoxy, hydroxy, C1-5alkyl, cyano, nitro, C1-5haloalkyl, RoRpN, RoRpNC═O, C2-8acyl, 4-7 membered heterocyclyl, (4-7 membered heterocyclyl)-C1-5alkylene, phenyl, (phenyl)C1-5alkylene, R14OC═O, R14S, R14SO, and R14SO2;
• R21 is selected from hydrogen, halogen, C1-5alkoxy, hydroxy, C1-5alkyl, cyano, nitro, C1-5haloalkyl, RcRdN, RcRdNC═O, C2-8acyl, 4-7 membered heterocyclyl, (4-7 membered heterocyclyl)-C1-5alkylene, phenyl, (phenyl)C1-5alkylene, R15OC═O, R15S, R15SO, and R15SO2;
• R2 is selected from hydrogen, halogen, C1-5alkoxy, hydroxy, C1-5alkyl, cyano, nitro, C1-5haloalkyl, ReRfN, ReRfNC═O, C2-8acyl, 4-7 membered heterocyclyl, (4-7 membered heterocyclyl)-C1-5alkylene, phenyl, (phenyl)C1-5alkylene, R16OC═O, R16S, R16SO, and R16SO2;
• R3 is selected from hydrogen, halogen, C1-5alkoxy, hydroxy, C1-5alkyl, cyano, nitro, C1-5haloalkyl, RgRhN, C2-8acyl, 4-7 membered heterocyclyl, (4-7 membered heterocyclyl)-C1-5alkylene, phenyl, (phenyl)C1-5alkylene, R17OC═O, RmRnNC═O, RmRnNSO2, R17S, R17SO, and R17SO2;
• R5 and R6 are independently selected from hydrogen and C1-5alkyl;
• R7 and R8 independently are hydrogen, C1-5alkyl, C1-5alkenyl, C1-5alkoxy, C1-5alkylthio, halogen, or 4-7 membered carbocyclyl or heterocyclyl;
• alternatively, R7 and R8 can be taken together to form an optionally substituted 5- to 7-membered carbocyclic or heterocyclic ring, which ring may be unsaturated or aromatic;
• said ring being optionally substituted with between 1 and 3 substituents independently selected from halo, hydroxy, cyano, nitro, amino, Rt, RtO—, RtS—, RtO(C1-5alkylene)-, RtO(C═O)—, Rt(C═O)—, Rt(C═S)—, Rt(C═O)O—, RtO(C═O)(C═O)—, RtSO2, NHRu(C═NH)—, NHRuSO2—, and NHRu(C═O)—;
• Rt is C1-6alkyl, phenyl, benzyl, phenethyl, or C2-5heterocyclyl, (C1-5heterocyclyl)C1-6alkylene, NH2, mono- or di(C1-6alkyl)N—, or R49OR50—, wherein R49 is H, C1-5alkyl, C2-5alkenyl, phenyl, benzyl, phenethyl, C1-5heterocyclyl, or (C1-5heterocyclyl)C1-6alkylene and R50 is C1-5alkylene, phenylene, or divalent C1-5heterocyclyl;
• and
• Ru can be H in addition to the values for Rt;
• Rc is hydrogen, C1-5alkyl, phenyl, C2-5heterocyclyl, C2-8acyl, aroyl, R10OC═O—, RiRjNC═O, R10SO—, R10SO2—, and RiRjNSO2;
• Re is hydrogen, C1-5alkyl, phenyl, C2-5heterocyclyl, C2-8acyl, aroyl, R40OC═O, R43R44NC═O, R40SO, R40SO2, and R43R44NSO2;
• Rm is hydrogen, C1-5alkyl, phenyl, C2-5heterocyclyl, C2-8acyl, aroyl, R41OC═O, R45R46NC═O, R41SO, R41SO2, and R45R46NSO2;
• Ro is hydrogen, C1-5alkyl, phenyl, C2-5heterocyclyl, C2-8acyl, aroyl, R42OC═O, R47R48NC═O, R42SO, R42SO2, and R47R48NSO2;
• each of Rd, Rf, Rn, and Rp is independently selected from hydrogen, C1-5alkyl, phenyl, and C2-5heterocyclyl;
• in addition, Rc and Rd, Re and Rf, Rm and Rn, or Ro and Rp, independently, can be taken together to form an optionally substituted 4- to 7-membered heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• each of R9, R10, R11, R14, R15, R16, R17, R40, R41, and R42 is independently C1-5alkyl, phenyl, or C2-5heterocyclyl;
• each of Ri and Rj, Rk and Rl, R43 and R44, R45 and R46, R47 and R48 are independently hydrogen, C1-5alkyl, C3-5alkenyl, phenyl, or C2-5heterocyclyl;
• in addition, Ri and Rj, and Rk and Rl, R43 and R44, R45 and R46, and R47 and R48, independently, can be taken together to form an optionally substituted 4- to 7-membered heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• Rg is hydrogen, C1-5alkyl, phenyl, or C2-5heterocyclyl, C2-8acyl, aroyl, R9OC═O, R18R19NC═O, R9SO, R9SO2, or R18R19NSO2;
• Rh is hydrogen, C1-5alkyl, phenyl, or C2-5heterocyclyl;
• alternatively, Rg and Rh can be taken together to form an optionally is substituted 4- to 7-membered heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• R18 and R19 independently are hydrogen, C1-5alkyl, phenyl, or C2-5heterocyclyl;
• alternatively, R18 and R19 can be taken together to form an optionally substituted 4- to 7-membered heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• n is 0, 1 or 2;
• G is C3-6alkenediyl or C3-6alkanediyl, optionally substituted with hydroxy, halogen, C1-5alkyl, C1-5alkoxy, oxo, hydroximino, CO2Rk, NRkRl, (L)-C1-4alkylene-, RkRlNCO2, [(L)-C1-5alkylene]amino, N3, or (L)-C1-5alkoxy;
• L is amino, mono- or di-C1-5alkylamino, pyrrolidinyl, morpholinyl, piperidinyl, homopiperidinyl, or piperazinyl, wherein available ring nitrogens can be optionally substituted with C1-5alkyl, benzyl, C2-5acyl, C1-5alkylsulfonyl, or C1-5alkoxycarbonyl;
• Ar represents a monocyclic or bicyclic aryl or heteroaryl ring, optionally substituted with between 1 and 3 substituents independently selected from halogen, C1-5alkoxy, C1-5alkyl, C2-5alkenyl, cyano, azido, nitro, R22R23N, R22S, R22SO, R22SO2, R22OC═O, R22R23NC═O, C1-5haloalkyl, C1-5haloalkoxy, C1-5haloalkylthio, and C1-5alkylthio;
• R22 is hydrogen, C1-5alkyl, C3-5alkenyl, phenyl, benzyl, C2-5heterocyclyl, C2-8acyl, aroyl, R11OC═O, R24R25NC═O, R11S, R11SO, R11SO2, or R24R25NSO2;
• R23 is hydrogen, C1-5alkyl, phenyl, benzyl, or C2-5heterocyclyl;
• alternatively, R22 and R23 can be taken together to form an optionally substituted 4- to 7-membered heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• R24 and R25 are independently hydrogen, C1-5alkyl, phenyl, benzyl, or C1-5heteroaryl;
• alternatively, R24 and R25 can be taken together to form an optionally substituted 4- to 7-membered carbocyclic or heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• R32 is hydrogen, C1-5alkyl, cyano, C1-5hydroxyalkyl, C2-8acyl, —(C═O)NRvRx, CHO, or C1-6alkoxycarbonyl, wherein each of Rv and Rx is independently selected from H, C1-5alkyl, C1-5hydroxyalkyl, C1-5heterocyclyl, (C1-5heterocyclyl) C1-5alkylene, C1-5aminoalkylene, C3-8acyloxy, CHO, C1-6alkoxycarbonyl, and cyano;
• Q is NR33, S, or O;
• R33 represents hydrogen, C1-5alkyl, phenyl, benzyl, phenethyl, C2-5heterocyclyl, (C2-5heterocyclyl)C1-5alkylene, C2-8acyl, aroyl, R35OC═O, R36R37NC═O, R35SO, R35S, R35SO2 and R36R37NSO2;
• R35 is selected from hydrogen, C1-5alkyl, phenyl, benzyl, phenethyl, and C2-5heteroaryl;
• R36 and R37 are each independently selected from hydrogen, C1-5alkyl, phenyl, or C2-5heteroaryl;
• alternatively, R36 and R37 can be taken together to form an optionally substituted 4- to 7-membered ring heterocyclic ring, which ring may be saturated, unsaturated or aromatic;
• wherein each of the above hydrocarbyl or heterocarbyl groups, unless otherwise indicated, and in addition to any specified substituents, is optionally and independently substituted with between 1 and 3 substituents selected from methyl, halomethyl, hydroxymethyl, halo, hydroxy, amino, nitro, cyano, C1-5alkyl, C1-5alkoxy, —COOH, C2-6acyl, [di(C1-4alkyl)amino]C2-5alkylene, [di(C1-4alkyl)amino] C2-5alkyl-NH—CO—, and C1-5haloalkoxy;
• or a pharmaceutically acceptable salt, amide, or ester thereof;
• or a stereoisomeric form thereof.