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US 6,635,628 B2Granted
Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects
AssigneeThe George Washington University
InventorsBernard Bouscarel, Kunihiko Kobayashi
Life of this patent
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Abstract
Methods of administering camptothecin compounds such as irinotecan hydrochloride to reduce a diarrhea side effect and methods of treating cancer and AIDs with camptothecin compounds including administering the camptothecin compounds while maintaining the intestinal lumen and the bile at an alkaline pH.
Claims1
A method of inhibiting a diarrhea side effect in a patient receiving a treatment with a camptothecin compound, the method comprising:
- administering a camptothecin compound selected from the group consisting of irinotecan hydrochloride CPT-11-Glu, SN-38-Glu, SN-38, 10,11-methylenedioxy-20(RS)-camptothecin, 9-amino-20(RS)-camptothecin and 7-hydroxy-methyl camptothecin in the amount of 10 mg/m2 to 700 mg/m2 to a patient in need thereof while maintaining the intestinal lumen of the patient at an alkaline pH of 7 to 10 by administering urso-deoxycholic acid to the patient to stimulate bicarbonate secretion into bile of the patient.
Dependencies are inferred from the claim text.