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AssigneeSociete Molecular Engines Laboratories
InventorsAdam Telerman, Robert Amson
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A compound that inhibits the cellular expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene, the compound comprising an antisense molecule comprising the antisense of a polynucleotide sequence selected from the group consisting of the entire polynucleotide sequence of the presenilin 1 gene, a fragment of the sequence of the presenilin 1 gene, the promoter or other regulatory sequence of the presenilin 1 gene and a polynucleotide sequence that is at least 90% homologous to the polynucleotide sequence of the presenilin 1 gene is described. Pharmaceuticals containing and methods of inhibiting the presenilin 1 gene using such compound are also described. A compound and method of inhibiting the expression product of the presenilin 1 gene also is described. A method of treating a patient having a condition characterized by excessive cell growth also is described. A method of diagnosing cancer also is described. A method of screening drugs that inhibit the presenilin 1 gene also is described. A compound and pharmaceutical that activates the presenilin 1 gene also is described as is a method of treating diseases associated with cell death.
A composition for inhibiting growth of tumor cells, comprising an effective inhibiting amount of an antisense polynucleotide 10-50 nucleobases in length targeted to a nucleic acid molecule encoding presenilin-1, wherein said antisense polynucleotide specifically hybridizes with and inhibits the expression of presenilin-1, and wherein said antisense polynucleotide comprises SEQ ID NO:
A method of reducing tumor cell growth, comprising introducing an effective inhibiting amount of a polynucleotide, which is antisense to all or part of the presenilin 1 gene set forth as SEQ ID NO:2, into tumor cells ex vivo and implanting cells containing said polynucleotide into a subject wherein cellular expression of the presenilin 1 gene is inhibited and whereby tumor reduction is obtained.
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