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AssigneesThe Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A&M University System
InventorsTimothy J. Foster, Kirk McCrea, Magnus A. O. Hook, Stacy Davis, Deirdre Ni Eidhin, Orla Hartford
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Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:16). The proteins, antigenic portions thereof and anti-SdrF, SdrG and SdrH antibodies are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, the proteins are advantageous because they may be used as vaccine components or antibodies thereof, and they may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.
An isolated nucleic acid molecule encoding a fibrinogen-binding protein, wherein the fibrinogen-binding protein is isolated from coagulase-negative Staphylococcus epidermidis and wherein the nucleic acid encodes SdrG and comprises SEQ ID NO:7.
An isolated nucleic acid comprising a sequence that selectively hybridizes to the nucleic acid sequence of SEQ ID NO:7.
An isolated nucleic acid molecule encoding a fibrinogen-binding protein that is cell wall-associated, exhibits cation-dependent ligand-binding and has a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:
Dependencies are inferred from the claim text.