Adenovirus serotype 30 (Ad30)
AssigneeUniversity of Iowa Research Foundation
InventorsBeverly L. Davidson, Lane K. Law
Life of this patent
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Abstract
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and viral particles and cells containing such expression vectors. The present invention further provides methods of treating genetic diseases or cancers in a mammal using the polynucleotides, polypeptides, expression vectors, viral particles and cells of the present invention.
Claims21
An isolated or purified polypeptide comprising SEQ ID NO:1.
An isolated or purified polypeptide comprising amino acids 1-188 of SEQ ID NO:1.
An isolated or purified polynucleotide comprising SEQ ID NO:12.
An isolated or purified polynucleotide comprising nucleotides 1-135 of SEQ ID NO:12.
An isolated or purified polynucleotide comprising a sequence encoding an Ad30 fiber region, wherein the fiber region is a shaft region, and wherein the shaft region comprises amino acids 46-188 of SEQ ID NO:1.
A polynucleotide encoding a chimeric Ad fiber polypeptide comprising a tail region, a shaft region and a knob region, wherein the polynucleotide encodes a chimeric Ad fiber polypeptide comprising an Ad5 tail region, an Ad30 shaft region and an Ad30 knob region, wherein the shaft region comprises amino acids 46-188 of SEQ ID NO:1.
An expression vector comprising an Ad backbone nucleic acid sequence and polynucleotide encoding a chimeric Ad fiber polypeptide comprising a tail region, a shaft region and a knob region, wherein the polynucleotide encodes an Ad5 tail region, an Ad30 shaft region and an Ad30 knob region, wherein the shaft region comprises amino acids 46-188 of SEQ ID NO:1.
Dependencies are inferred from the claim text.