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AssigneeThird Wave Technologies, Inc.
InventorsWu-Po Ma, Victor I. Lyamichev, Michael W. Kaiser, Natalie E. Lyamicheva, Hatim Taysir Allawi, James J. Schaefer, Bruce P. Neri
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The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that cleave the nucleic acid cleavage structure in a site-specific manner to produce non-target cleavage products. The present invention provides enzymes having an improved ability to specifically cleave a DNA member of a complex comprising DNA and RNA nucleic acid strands.
A composition comprising a polypeptide, said polypeptide comprising SEQ ID NO:280.
A composition comprising a polypeptide encoded by a nucleic acid, said nucleic acid comprising SEQ ID NO:279.
A composition comprising a polypeptide encoded by a nucleic acid that hybridizes to the complement of SEQ ID NO:279 under stringent conditions.
Dependencies are inferred from the claim text.