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US 6,635,462 B1Granted
Mutated form of arginine deiminase
AssigneePhoenix Pharmacologies, Inc.
InventorsCharles Mark Ensor, Frederick Wayne Holtsberg, Mike A. Clark
Life of this patent
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Abstract
The present invention discloses arginine deiminase that is genetically modified for more efficient manufacturing and processing. The present invention discloses recombinant DNA molecules and vectors and other therapeutic and pharmaceutical compositions. The present invention also discloses methods for preparing modified arginine deiminase as well as methods of treating cancer and other disease states using modified arginine deiminase.
Claims13
An arginine deiminase isolated from Mycoplasma hominis comprising the amino acid sequence of SEQ ID NO:
- 1, wherein said deiminase has been modified by elimination of at least one pegylation site at or adjacent to the catalytic region of the delminase.
Dependencies are inferred from the claim text.