Polynucleotides encoding a novel interleukin receptor termed interleukin-17 receptor-like protein
AssigneeHuman Genome Sciences, Inc.
InventorsYanggu Shi, Steven M. Ruben
Life of this patent
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Abstract
The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
Claims60
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
- (a) a polynucleotide sequence encoding amino acid residues −19 to +407 of SEQ ID NO:2;
- (b) a polynucleotide sequence encoding amino acid residues −18 to +407 of SEQ ID NO:2;
- (c) a polynucleotide sequence encoding amino acid residues +1 to +407 of SEQ ID NO:2;
- (d) a polynucleotide sequence encoding amino acid residues +1 to +271 of SEQ ID NO:2;
- (e) a polynucleotide sequence encoding the full-length polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
- (f) a polynucleolide sequence encoding the full-length polypeptide, excluding the N-terminal methionine residue, having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
- (g) a polynucleotide sequence encoding the mature polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
- (h) a polynucleotide sequence encoding the extracellular domain of the polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
- and
- (i) a polynucleotide sequence complementary to any one of the polynucleotide sequences in (a), (b), (c), (d), (e), (f), (g) or (h), above.
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
- (a) a polynucleotide sequence encoding a polypeptide having the amino acid sequence consisting of residues n1 to +407 of SEQ ID NO:2, where n1 is an integer in the range of −19 to +5;
- (b) a polynucleotide sequence encoding a polypeptide having the amino acid sequence consisting of residues −19 to m1 of SEQ ID NO:2, where m1 is an integer in the range of +340 to +407;
- (c) a polynucleotide sequence encuding a polypeptide having the amino acid sequence consisting of residues n1 to m1 of SEQ ID NO:2, where n1 is an integer in the range of −19 to +5 and m1 is an integer in the range of +340 to +407,
- (d) a polynucleotide sequence encoding a polypeptide consisting of a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 209198 wherein said portion excludes up to 24 amino acids from the amino terminus of said complete amino acid sequence;
- (e) a polynucleotide sequence encoding a polypeptide consisting of a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 209198 wherein said portion excludes up to 67 amino acids from the C-terminus of said complete amino acid sequence;
- (f) a polynucleotide sequence encoding a polypeptide consisting of a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 209198 wherein said portion excludes up to 24 amino acids from the amino terminus and up to 67 amino acids from the C-terminus of said complete amino acid sequence;
- and
- (g) a polynucleotide sequence complementary to any one of the nucleic acid sequences in (a), (b), (c), (d), (e) or (f), above.
A recombinant host cell comprising the isolated nucleic acid molecule of 20.
An isolated nucleic acid molecule comprising a first polynucleotide sequence encoding a polypeptide 90% or more identical to that encoded by a second polynucleotide sequence selected from the group consisting of:
- (a) a second polynucleotide sequence encoding amino acid residues −19 to +407 of SEQ ID NO:2;
- (b) a second polynucleotide sequence encoding amino acid residues −18 to +407 of SEQ ID NO:2;
- (c) a second polynucleotide sequence encoding amino acid residues +1 to +407 of SEQ ID NO:2;
- (d) a second polynucleotide sequence encoding amino acid residues +1 to +271 of SEQ ID NO:2;
- (e) a second polynucleotide sequence encoding the full-length polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
- (f) a second polynucleotide sequence encoding the mature polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198;
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- (g) a second polynucleotide sequence encoding the extracellular domain of the polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209198, wherein said isolated nucleic acid molecule encodes a polypeptide having activity in stimulating leukocyte proliferation, leukocyte differentiation, or IL-6 secretion.
Dependencies are inferred from the claim text.