LSR receptor, activity, cloning, and uses for diagnosing, preventing and/or treating obesity and related risks or complications
AssigneesGenset S.A., Institute National de la Sante et de la Recherche Medicale (INSERM)
InventorsBernard Bihain, Lydie Bougueleret, Frances Yen-Potin
Life of this patent
Estimating the term…
Abstract
The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds which can be used as medicament for the prevention and/or treatment of pathologies and/or of pathogeneses such as obesity and anorexia, hyperlipidemias, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with abnormalities in the metabolism of cytokines.
Claims57
A purified or recombinant Lipolysis Stimulated Receptor, wherein said receptor comprises a polypeptide comprising the amino acid sequence of SEQ ID NO:12.
A purified or recombinant Lipolysis Stimulated Receptor, wherein said receptor comprises a biologically active polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) an amino acid sequence spanning amino acids 76 to 545 of SEQ ID NO:12;
- b) an amino acid sequence spanning amino acids 76 to 160 of SEQ ID NO:12;
- c) an amino acid sequence spanning amino acids 76 to 237 of SEQ ID NO:12;
- d) an amino acid sequence spanning amino acids 157 to 462 of SEQ ID NO:12;
- e) an amino acid sequence spanning amino acids 236 to 462 of SEQ ID NO:12;
- and
- f) an amino acid sequence spanning amino acids 236 to 545 of SEQ ID NO:12.
A recombinant polypeptide comprising the amino acid sequence of SEQ ID NO:12.
An isolated or recombinant biologically active polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) an amino acid sequence spanning amino acids 76 to 545 of SEQ ID NO:12;
- b) an amino acid sequence spanning amino acids 76 to 160 of SEQ ID NO:12;
- c) an amino acid sequence spanning amino acids 76 to 237 of SEQ ID NO:12;
- d) an amino acid sequence spanning amino acids 157 to 462 of SEQ ID NO:12;
- e) an amino acid sequence spanning amino acids 236 to 462 of SEQ ID NO:12;
- and
- f) an amino acid sequence spanning amino acids 236 to 545 of SEQ ID NO:12.
Dependencies are inferred from the claim text.