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US 6,635,430 B1Granted
Filtrate plate device and reversible-well plate device
AssigneeDuPont Pharmaceuticals Company
InventorMicky D. Tortorella
Life of this patent
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Abstract
This invention is directed to filtrate-holder and reversible-well collection plates composed of polypropylene and Teflon®, and to their use, in connection with compatible filter units, in high-throughput screening assays for assessing the binding of small molecules to proteins.
Claims9
A filtrate-holder plate comprising polypropylene and polytetrafluoroethylene resin and containing a plurality of wells, wherein:
- each of said wells is capable of securely containing a centrifugal filter unit having a base, reservoir and filter membrane;
- said wells contain an opening on their bottom surface sufficient in size to allow said base of said filter unit, but not said reservoir or filter membrane of said filter unit, to pass through said bottom surface and into a reversible-well collection plate;
- said wells having a circular circumference;
- and wherein:
- said filtrate-holder plate has side surfaces and an exterior bottom surface that contains a plurality of pegs protruding therefrom sufficient in number and size to connect said plate to a reversible-well collection plate;
- and
- said side and bottom surfaces of said filtrate-holder plate contain a plurality of V-shaped grooves sufficient in number and size to allow said filtrate-holder plate to be held by a standard automated device.
4 more elements
In combination, a filtrate-holder plate and a plurality of filter units, wherein:
- said filter-holder plate comprises a substrate having a top surface, a bottom surface and a thickness, said substrate having a plurality of holes in said thickness arranged in an array;
- each of said plurality of filter units comprises a base having a perimeter, a reservoir and a membrane between said base and said reservoir, the length of said base being greater than said thickness of said substrate;
- each of said plurality of holes is configured to receive said base of a respective one of said plurality of filter units such that said base extends through said hole and beyond said bottom surface of said substrate;
- and
- said substrate comprises a blend of polytetrafluoroethylene resin and polypropylene.
2 more elements
Dependencies are inferred from the claim text.