Gastric retaining oral liquid dosage form
AssigneeAlza Corporation
InventorsPatrick S.-L. Wong, David E. Edgren
Life of this patent
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Abstract
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
Claims9
A dosage form comprising:
- a bioerodible carrier formulated to facilitate retention of the dosage form within a stomach of a subject and erode over a prolonged period of time as the dosage form is retained in the stomach;
- and
- a plurality of porous particles having a liquid active agent formulation absorbed therein, wherein said plurality of porous particles is dispersed within said bioerodible carrier, the porosity of said plurality porous particles is such that liquid active agent formulation comprises at least about 5% and up to about 70% of die weight of the plurality of porous particles said plurality of porous particles is adapted to resist compaction forces sufficient to form a compacted drug layer without significant exudation of the liquid active agent formulation, the dosage form is formulated such that porous particles included in said plurality of porous particles are released from the dosage form as said bioerodible carrier erodes in the stomach;
- and said liquid active agent formulation is formulated such that 70% or more of an active agent included in said liquid active agent formulation is released from said plurality of porous particles within about 20 minutes from introduction of said porous particles into a fluid environment of use.
Dependencies are inferred from the claim text.