Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same
AssigneeDenki Kagaku Kogyo Kabushiki Kaisha
InventorsTeruzou Miyoshi, Hironoshin Kitagawa, Kazuhiko Arai, Hiroshi Kaneko, Toshihiko Umeda
Life of this patent
Estimating the term…
Abstract
A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and has fluidity enough to be easily ejectable from an injector.
Claims16
A hyaluronic acid gel, comprising water and hyaluronic acid, wherein said hyaluronic acid is not in the form of a complex with a cationic polymer and wherein the hyaluronic acid gel is autocrosslinked, hardly soluble in a neutral aqueous solution, and has fluidity enough to be easily ejectable from an injector, and
- wherein said hyaluronic acid gel dissolves to yield solubilized hyaluronic acid having a branched structure and comprising a molecular weight fraction with a branching degree of at least 0.5, when treated under accelerating conditions for acid hydrolysis of hyaluronic acid.
A biomedical material comprising a hyaluronic acid gel which satisfies the following requirements (a)-(c):
- (a) the hyaluronic acid gel dissolves in a neutral aqueous solution at 37° C. in 12 hours to a degree of dissolution of at most 50%,
- (b) the hyaluronic acid gel dissolves to yield solubilized hyaluronic acid having a branched structure and containing a molecular weight fraction with a branching degree of at least 0.5, when treated under accelerating conditions for acid hydrolysis of hyaluronic acid, and
- (c) the hyaluronic acid gel is autocrosslinked.
A biomedical material comprising an autocrosslinked hyaluronic acid gel and un-gelled hyaluronic acid, wherein the hyaluronic acid gel dissolves in a neutral aqueous solution at 37° C. in 12 hours to a degree of at most 50%, and the hyaluronic acid gel dissolves to yield solubilized hyaluronic acid having a branched structure and containing a molecular weight fraction with a branching degree of at least 0.5, when treated under accelerating conditions for acid hydrolysis of hyaluronic acid.
Dependencies are inferred from the claim text.