Surface modification of lamellar particles
AssigneeWest Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited
InventorsStanley Stewart Davis, Andrew Wells
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Abstract
Lamellar particles are provided comprising a biodegradable and biocompatible polymer and carrying a cationic charge on their surface. These particles are prepared by mixing a preformed negatively charged lamellar particle with a positively charged material. Compositions using these particles may include genetic material or antigens, for example, and may be used as a drug delivery system, such as a sustained release system.
Claims11
A lamellar particle which is not a liposome and which comprises a biodegradable and biocompatible polymer and carries a cationic charge on its surface, wherein the cationic charge arises from a cationic material attached to or incorporated into the particle, and the cationic material is selected from the group consisting of DEAE-dextran and polyethyleneimine.
Dependencies are inferred from the claim text.