Single-chain antibody fragments for transferring substances into cells
AssigneesInstitut Pasteur, Universite Pierre et Marie Curie
InventorsTherese Ternynck, Alexandre Avrameas, Gerard Buttin, Stratis Avrameas, Marie-Francoise Saron, Bruno Blondel, Therese Couderc, Susan Michelson, Donato Zipeto
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Abstract
The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
Claims21
An isolated polypeptide, consisting of a single chain of amino acids, wherein said single chain of amino acids comprises one or more penetrating fragments from one or more penetrating antibodies, and wherein said isolated polypeptide penetrates into a cell.
An isolated polypeptide, consisting of a polylysine region and a single chain of amino acids from a penetrating polyreactive antibody, wherein the isolated polypeptide penetrates into a cell.
Dependencies are inferred from the claim text.