Method of sterilizing products
AssigneeClearant, Inc.
InventorRandall S. Kent
Life of this patent
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Abstract
A method for sterilizing products to inactivate biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites is disclosed. The method involves irradiating the product at a low dose rate from about 0.1 kGy/hr. to about 3.0 kGy/hr. for a period of time sufficient to sterilize the product. The method does not destroy sensitive materials such as blood and blood components. Further, the method does not require pre-treatment of the product such as freezing, filtration or the addition of chemical sensitizers.
Claims19
A method for sterilizing a biological product comprising irradiating the product with gamma irradiation at a rate of from about 0.25 kGy/hr. to about 20 kGy/hr. for a period of time sufficient to sterilize the product, wherein said biological product contains at least one biological material selected from the group consisting of:
- dextrose, antibodies, IgG, albumin, alpha 1 proteinase inhibitor, fibrinogen, Factor VII, Factor VIII, Factor IX, pharmaceuticals, nucleic acids, body fluids, saliva, cerebral spinal fluid, liposomes, glucose, cell culture media, fetal bovine serum, bone marrow and organs.
A method for sterilizing a biological product comprising irradiating the product at ambient temperature or below with gamma irradiation at a rate of from about 0.1 kGy/hr. to about 3.0 kGy/hr. for a period of time sufficient to sterilize the product, wherein said biological product contains at least one biological material selected from the group consisting of:
- dextrose, antibodies, IgG, albumin, alpha 1 proteinase inhibitor, fibrinogen, Factor VII, Factor VIII, Factor IX, pharmaceuticals, nucleic acids, body fluids, saliva, cerebral spinal fluid, liposomes, glucose, cell culture media, fetal bovine serum, bone marrow and organs.
A method for sterilizing a biological product comprising irradiating the product with gamma irradiation at a rate of from about 0.1 kGy/hr. to about 3.0 kGy/hr for a period of time sufficient to sterilize the product, wherein said biological product contains at least one biological material selected from the group consist of:
- dextrose, antibodies, IgG, albumin, alpha 1 proteinase inhibitor, fibrinogen, Factor VII, Factor VIII, Factor IX, pharmaceuticals, nucleic acids, body fluids, saliva, cerebral spinal fluid, liposomes, glucose, cell culture media, fetal bovine serum, bone marrow and organs.
A method for sterilizing a biological product comprising irradiating the product with gamma irradiation at a rate of from about 0.1 kGy/hr. to about 3.0 kGy/hr. for a period of time greater than 10 hours, wherein said biological product contains at least one biological material selected from the group consisting of:
- dextrose, antibodies, IgG, albumin, alpha 1 proteinase inhibitor, fibrinogen, Factor VII, Factor VIII, Factor IX, pharmaceuticals, nucleic adds, body fluids, saliva, cerebral spinal fluid, liposomes, glucose, cell culture media, fetal bovine serum, bone marrow and organs.
Dependencies are inferred from the claim text.