Electrodes and method for manufacturing electrodes for electrically assisted drug delivery
AssigneeVyteris, Inc.
InventorsPreston Keusch, Uday K. Jain, Vilambi Nrk Reddy, Bruce M. Eliash, Kevin John Carey, Vitaly Falevich
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Abstract
Provided is a method for loading electrode-corroding ingredients into an un-loaded donor gel reservoir of an electrode for an electrically assisted drug delivery system. The method provides that a salt, such as sodium chloride or an organic salt, is provided in the un-loaded donor gel reservoir, contrary to convention. Related electrically assisted drug delivery electrode assemblies also are provided.
Claims19
A method for making an electrode assembly for electrically assisted transmembrane delivery of an active ingredient, comprising the steps of:
- a. providing an unloaded electrode assembly comprising a Ag/AgCl electrode and a reservoir comprising a polymer having an aqueous composition dispersed therein, the aqueous composition comprising an amount of salt effective to inhibit electrode corrosion;
- and
- b. contacting a surface of the reservoir with an aqueous loading solution comprising an active electrode-corrosive ingredient for an amount of time effective to permit loading of a predetermined amount of the active electrode-corrosive ingredient into the reservoir.
An electrode prepared according to a process for preparing the electrode comprising the steps of:
- a. providing an unloaded electrode assembly comprising a Ag/AgCl electrode and a reservoir comprising a polymer having an aqueous composition dispersed therein, the aqueous composition comprising an amount of salt effective to inhibit electrode corrosion;
- and
- b. contacting a surface of the reservoir with an aqueous loading solution comprising an active electrode-corrosive ingredient for an amount of time effective to permit loading of a predetermined amount of the active electrode-corrosive ingredient into the reservoir.
Dependencies are inferred from the claim text.