Haemofiltration machine for independently controlling the concentration of a least two ionic substances in a patient's internal medium

A hemofiltration machine, comprising:

• a hemofilter having a first compartment and a second compartment separated by a semi-permeable membrane, the first compartment having an inlet and an outlet, the second compartment having an outlet configured to be connected to a spent liquid evacuation tube;
• a blood withdrawing tube coupled to the inlet of the first compartment, the blood withdrawing tube being configured to direct blood flow from a patient to the hemofilter;
• a blood return tube coupled to the outlet of the first compartment, the blood return tube being configured to direct the blood flow from the hemofilter to the patient;
• a solution generator configured to prepare a first solution from at least one concentrated solution;
• a first infusion assembly configured to inject the first solution into the blood withdrawing tube at a first infusion flow rate;
• a second infusion assembly configured to inject a second solution into the blood flow, the second solution containing at least one ionic substance having a given concentration that is different from a concentration of said at least one ionic substance in the first solution;
• and
• a controller configured to determine an infusion flow rate of the second solution in order for the concentration of the substance A in the patient's internal medium to tend towards a desired concentration, the infusion flow rate of the second solution being a function of the concentration of said at least one ionic substance in the second solution, the desired concentration, the infusion flow rate of the first solution, and blood flow rate.

Haemofiltration machine designed to cooperate with a haemofilter having a first compartment and a second compartment separated by a semi-permeable membrane, the first compartment having an inlet which can be connected to a blood withdrawing tube and an outlet which can be connected to a blood return tube, and the second compartment having an outlet which can be connected to a spent liquid evacuation tube, the haemofiltration machine comprising:

• means for preparing a first injectable solution from at least one concentrated solution;
• means for injecting, at an injection flow rate Qpre, the first solution into the blood withdrawing tube;
• means for infusing directly into a patient's blood a second solution containing at least one ionic substance A having a given concentration [A]post which is different from the concentration [A]pre of this substance A in the first solution;
• means for determining an infusion flow rate Qpost of the second solution in order for the concentration of the substance A in the patient's internal medium to tend towards a desired concentration [A]des, as a function of the concentration [A]post of the substance A in the second solution, the desired concentration [A]des, the injection flow rate Qpre of the first solution and the blood flow rate QB;
• and
• control means for governing the infusion means such that the flow rate of the second solution is substantially equal to the determined flow rate Qpost.

Haemofiltration machine designed to cooperate with a haemofilter having a first compartment and a second compartment separated by a semi-permeable membrane, the first compartment having an inlet which can be connected to a blood withdrawing tube and an outlet which can be connected to a blood return tube, and the second compartment having an outlet which can be connected to a spent liquid evacuation tube, the haemofiltration machine comprising:

• means for preparing a first injectable solution from at least one concentrated solution;
• means for injecting, at an injection flow rate Qpre, the first solution into the blood withdrawing tube;
• means for infusing into the a patient a second solution containing at least one ionic substance A having a given concentration [A]post which is different from the concentration [A]pre of this substance A in the first solution;
• means for determining an infusion flow rate Qpost of the second solution in order for the concentration of the substance A in the patient's internal medium to tend towards a desired concentration [A]des, as a function of the concentration [A]post of the substance A in the second solution, the desired concentration [A]des, the injection flow rate Qpre of the first solution and the blood flow rate QB, the substance A being absent from the first solution and the means for determining the infusion flow rate Qpost comprising calculation means for calculating the infusion flow rate Qpost according to the formula:
• Q post = ( A ) des × Q B × Q pre ( A ) post × Q B + ( A ) post × Q pre - ( A ) des × Q B ;
• ⁢ and
• control means for governing the infusion means such that the flow rate of the second solution is substantially equal to the determined flow rate Qpost.