Method translation in gas chromatography
OwnerLeonid M. Blumberginventor
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Abstract
A method is provided for translating from a first method for performing gas chromatographic analysis to a second method for performing gas chromatographic analysis in a gas chromatography system without changing a peak elution pattern. Unlike the known method translation techniques that work only with the constant pressure gas chromatographic analyses, the invention can translate the gas chromatographic methods where column pressure and/or carrier gas flow rate change during the analysis by an arbitrary program.
Claims16
A method for method translation from a first method for performing gas chromatographic analysis to a second method for performing gas chromatographic analysis in a gas chromatography system, the method comprising the steps of:
- translating from a temperature program based on time in the first method to a normalized temperature program, the normalized temperature program based on a dimensionless time, τ, wherein τ = ∫ 0 t ⅆ t / t M
- where tM is void time and wherein void time is the time for an unretained solute to travel through the gas chromatography system;
- and
- generating a temperature program for the second method based on the normalized temperature program and a set of pre-selected conditions for the second method.
A method for translation from an original method for performing a gas chromatographic analysis to a translated method for performing a gas chromatographic analysis where
- the translation is done in a way that a dimensionless retention time of any solute in a gas chromatographic analysis, hereinafter translated analysis, performed according to a translated method is the same as a dimensionless retention time of that solute in a gas chromatographic analysis, hereinafter original analysis, performed according to the original method;
- and where
- either the original method or the translated method or both methods can have a temperature program for changing a column temperature during a gas chromatographic analysis, and/or a pneumatic program for changing pneumatic parameters during a gas chromatographic analysis wherein a pneumatic parameter is a carrier gas flow rate or a carrier gas velocity or a column head pressure or a column outlet pressure or a compressed pressure drop or another parameter, other than column temperature, that affects a value of one or more of the above mentioned pneumatic parameters in a programmable way.
Dependencies are inferred from the claim text.