Method for controlling a coating process
AssigneeAstraZeneca AB
InventorsStaffan Folestad, Ingela Niklasson Björn
Life of this patent
Estimating the term…
Abstract
This invention relates to a method for controlling the process of manufacturing a coating of a pharmaceutical product, comprising the steps of: performing a spectroscopic measurement on the coating; generating a sample vector of measurement values from the spectrometric measurement; condensing the measurement values into at least one principal parameter; comparing the principal parameter to a predetermined corresponding model parameter; determining deviations of the principal parameter from the corresponding model parameter and extracting information directly related to the quality of the coating; and controlling the process on the basis, at least partly, of the extracted information.
Claims20
A method for controlling the process of manufacturing a coating of a pharmaceutical product, wherein the method comprises monitoring simultaneously principal parameters relating to properties of the coating by performing the following steps comprising:
- (a) performing a spectrometric measurement on said coating;
- (b) generating a sample vector of a plurality of measurement values from said spectrometric measurement;
- (c) condensing said measurement values into principal parameters relating to properties of the coating;
- (d) comparing said principal parameters to predetermined corresponding model parameters;
- (e) determining deviations of said principal parameters from said corresponding model parameters and extracting information directly related to the quality of said coating;
- and
- (f) controlling the process at least partly on the basis of said information by applying instant feedback control to the process in relation to the magnitude of the deviation of said principal parameters.
A pharmaceutical product comprising a coating, the coating applied by a method controlled by a process comprising the steps of:
- (a) performing a spectrometric measurement on said coating;
- (b) generating a sample vector of a plurality of measurement values from said spectrometric measurement;
- (c) condensing said measurement values into principal parameters relating to properties of the coating;
- (d) comparing said principal parameters to predetermined corresponding model parameters;
- (e) determining deviations of said principal parameters from said corresponding model parameters and extracting information directly related to the quality of said coating;
- and
- (f) controlling the process at least partly on the basis of said information by applying instant feedback control to the process in relation to the magnitude of the deviation of said principal parameters.
A method for controlling the process of manufacturing a coating of a pharmaceutical product, wherein the method comprises monitoring simultaneously principal parameters relating to properties of the coating by performing the following steps comprising:
- (a) performing a spectrometric measurement on said coating;
- (b) generating a sample vector of a plurality of measurement values from said spectrometric measurement;
- (c) condensing said measurement values into principal parameters relating to properties of the coating;
- (d) comparing said principal parameters to predetermined corresponding model parameters;
- (e) determining deviations of said principal parameters from said corresponding model parameters and extracting information directly related to the quality of said coating;
- and
- (f) adjusting the process at least partly on the basis of said information by applying instant feedback control to the process in relation to the magnitude of the deviation of said principal parameters.
Dependencies are inferred from the claim text.