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US 6,632,955 B1Granted
Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
AssigneeChisso Corporation
InventorsMasakatsu Shibasaki, Hiroaki Sasai, Yasuo Urata, Mamoru Fujita
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Abstract
Optically active 1-substituted phenyl-2-nitro alcohol derivatives having the formula (1) and the process for producing thereof, and 1-substituted phenyl-2-amino alcohol derivatives having the formula (2) and the process for producing thereof from the optically active 1-substituted phenyl-2-nitro alcohol derivatives. From these nitro alcohols, pharmaceuticals such as (R)-albutamin and (R)-sarmeterol useful as a bronchodilator is obtained via optically active amino alcohols which are useful pharmaceutical intermediates.
Claims1
An optically active alcohol of the following formula (1-1)
- in which R5 and R6 both represent a t-butyldimethylsilyl group, respectively;
- R4 represents a hydrogen atom;
- and * represents an optically active site.
Dependencies are inferred from the claim text.