Process for production of optically active pyrroloazepine derivatives
AssigneeDaiichi Suntory Pharma Co., Ltd.
InventorsAkira Mizuno, Kazuto Sekiuchi, Takushi Nagata, Teruo Muraishi
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Abstract
It is provided a method for preparing the pyrroloazepine derivatives, especially in optically active form useful as drugs, by low-priced and simple method and in industrial applicable scale, represented by the following formula (I): wherein Z represents optionally substituted phenyl group, which comprises; a process for the asymmetric reduction of ketone compound with metal hydride compound and alcohol compound in the presence of optically active cobalt complex catalyst, and a process for the purification of the resulting compound.
Claims48
A method for preparing the optically active pyrroloazepine compounds represented by formula (I):
- wherein Z represents an optionally substituted phenyl group, said method comprising;
- asymmetrically reducing a ketone represented by formula (II):
- with a metal hydride and an alcohol in the presence of an optically active cobalt complex catalyst, and
- purifying the resulting compound.
A method for preparing the optically active pyrrloazepine compounds represented by formula (I):
- wherein Z represents an optionally substituted phenyl group, said method comprising;
- asymmetrically reducing a ketone represented by formula (III):
- wherein Y represents a halogen atom, with a metal hydride and an alcohol in the presence of an optically active cobalt complex catalyst to obtain the optically active alcohol represented by formula (IV):
- reacting the resulting alcohol compound of the formula (IV) with the piperazine compound represented by formula (V) or a salt thereof:
- and purifying the resulting compound.
A method for preparing the optically active pyrroloazepine compounds represented by formula (IV):
- wherein Y represents a halogen atom, said method comprising asymmetrically reducing the ketone compound represented by formula (III):
- wherein Y represents a halogen atom, with a metal hydride and an alcohol in the presence of an optically active cobalt complex catalyst.
Dependencies are inferred from the claim text.