Antibody variants
AssigneeGenentech, Inc.
InventorsYvonne M. Chen, Henry B. Lowman, Yves Muller
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Abstract
Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
Claims3
A heavy chain variable domain of an antibody that binds vascular endothelial growth factor (VEGF) comprising the amino acid sequence of SEQ ID NO:98 or SEQ ID NO:99.
An antibody variant that binds vascular endothelial growth factor (VEGF) and comprises the heavy and light chain variable domains of Y0239-19 (SEQ ID NOS:
- 98 and 95, respectively).
An antibody variant that binds vascular endothelial growth factor (VEGF) and comprises the heavy and light chain variable domains of Y0313-2 (SEQ ID NOS:
- 99 and 95, respectively).
Dependencies are inferred from the claim text.