Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
AssigneeBoston Heart Foundation, Inc.
InventorsAnn M. Lees, Robert S. Lees, Simon W. Law, Anibal A. Arjona
Life of this patent
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Abstract
Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
Claims33
An isolated polypeptide that binds to LDL and has at least 80% sequence identity to the amino acid sequence of SEQ ID NO:7.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:7.
An isolated polypeptide that binds to LDL and has at least 80% sequence identity to the amino acid sequence of SEQ ID NO:43.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:43.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and has at least 80% sequence identity to the amino acid sequence of SEQ ID NO:7.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and has at least 80% sequence identity to the amino acid sequence of SEQ ID NO:43.
An isolated polypeptide comprising a peptide sequence that (i) binds to LDL and (ii) is identical to a fragment of at least ten amino acid residues of SEQ ID NO:7.
An isolated polypeptide comprising a peptide sequence that (i) binds to LDL and (ii) is identical to a fragment of at least ten amino acid residues of SEQ ID NO:43.
An isolated polypeptide that binds to LDL and whose sequence differs by one or more conservative amino acid substitutions from the amino acid sequence of SEQ ID NO:7.
An isolated polypeptide that binds to LDL and whose sequence differs by one or more conservative amino acid substitution from the amino acid sequence of SEQ ID NO:43.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and differs by one or more conservative amino acid substitutions from the amino acid sequence of SEQ ID NO:7.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and differs by one or more conservative amino acid substitutions from the amino acid sequence of SEQ ID NO:43.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and differs by one or more conservative amino acid substitutions from the amino acid sequence of a fragment of at least 30 consecutive amino acid residues of SEQ ID NO:
- 7.
An isolated polypeptide comprising a peptide sequence, wherein the peptide sequence binds to LDL and differs by one or more conservative amino acid substitutions from the amino acid sequence of a fragment of at least 30 consecutive amino acid residues of SEQ ID NO:
- 43.
Dependencies are inferred from the claim text.