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AssigneeThe Regents of the University of California
InventorsTimothy J. Deming, Miaoer Yu, Scott A. Curtin, Jungyeon Hwang, Michael D. Wyrsta
Estimating the term…
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functionalized aninoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
A method of making a mixture containing an amido-containing metallacycle and a solvent comprising combining an alloc-amino acid amide, wherein alloc- is an allyloxycarbonyl group, with an initiator comprising a low valent transition metal-Lewis Base ligand complex in a suitable solvent for a time and under conditions effective to form a mixture containing an amido-amidate metallacycle and the solvent.
A method of making an amido-containing metallacycle comprising:
Dependencies are inferred from the claim text.