Use of bissulfonamides for producing medicines for the treatment of hyperlipidemia

A method of treating hyperlipidemia, comprising administering to a patient in need thereof an effective amount of at least one compound of formula I,

• in which:
• X, R1, and R2 are, independently of one another, NR6R7, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or tetrahydropyridinyl, in which each ring is optionally substituted by phenyl, (C1-C6)-alkyl-phenyl, (C1-C6)-alkyl, (C1-C6)-alkyl-OH, O-phenyl, S-phenyl, (CO)—(C1-C6)-alkyl, or (CO)-phenyl, where the phenyl substituent is unsubstituted or mono- or disubstituted by F, Cl, Br, OH, CF3, CN, OCF3, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, SO—(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, COOH, COO(C1-C6)alkyl, COO(C3-C6)cycloalkyl, CONH2, CONH(C1-C6)alkyl, CON[(C1-C6)alkyl]2, CONH(C3-C6)cycloalkyl, NH2, NH—CO—(C1-C6)-alkyl, or NH—CO-phenyl;
• R6 and R7 are, independently of one another, H, (C1-C6)-alkyl, (C1-C6)-alkyl-O—(C1-C6)-alkyl, O—(C1-C6)-alkyl, (C3-C6)-cycloalkyl, CO—(C1-C6)-alkyl, (C1-C6)-alkyl-NH—C(O)—(C1-C6)-alkyl, (C1-C6)-alkyl-NH—(C1-C6)-alkyl, (C1-C6)-alkyl-N—[(C1-C6)-alkyl]2, (C1-C6)-alkyl-O-phenyl, CHO, CO-phenyl, or (CH2)n—Ar, where n is the integer 0, 1, 2, 3, 4, 5, or 6, and Ar is chosen from phenyl, biphenylyl, 1- or 2-naphthyl, 1- or 2-tetrahydrofuranyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furyl, 2-, 4-, or 5-thiazolyl, 2-, 4-, or 5-oxazolyl, 1-pyrazolyl, 3-, 4-, or 5-isoxazolyl, (C3-C6)-cycloalkyl, piperidinyl, pyrrolidinyl, 2- or 3-pyrrolyl, 2- or 3-pyridazinyl, 2-, 4-, or 5-pyrimidinyl, 2-pyrazinyl, 2-(1,3,5-triazinyl), 2-, 3-, or 4-morpholinyl, 2- or 5-benzimidazolyl, 2-benzothiazolyl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, tetrazol-5-yl, indol-3-yl, indol-5-yl, or N-methyl-imidazol-2-, -4-, or -5-yl, and Ar is optionally mono- or disubstituted by F, Cl, Br, OH, CF3, NO2, CN, OCF3, O—CH2—O, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, SO—(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, COOH, COO(C1-C6)alkyl, COO(C3-C6)cycloalkyl, CONH2, CONH(C1-C6)alkyl, CON[(C1-C6)alkyl]2, CONH(C3-C6)cycloalkyl, NH2, NH—CO—(C1-C6)-alkyl, NH—CO-phenyl, pyrrolidin-1-yl, morpholin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-methyl-piperazin-1-yl, (CH2)n-phenyl, O—(CH2)n-phenyl, S—(CH2)n-phenyl, or SO2—(CH2)n-phenyl, where n is the integer 0, 1, 2, or 3;
• or a salt or ester thereof.