Compositions and methods for treating conditions responsive to estrogen
AssigneePfizer Inc.
InventorsDavid D. Thompson, Andrew G. Lee, Wesley W. Day, Robert L. Rosati
Life of this patent
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Abstract
This invention relates to methods, pharmaceutical compositions and kits useful in treating conditions responsive to estrogen by the administration of estrogen agonists/antagonists. Conditions responsive to the compositions and methods include rheumatoid arthritis, colon cancer, tissue wounds, skin wrinkles and cataracts. The compositions are comprised of an estrogen agonist/antagonist and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration.
Claims2
A method of treating colon cancer, the method comprising administering to a subject in need thereof, an effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or an optical or geometric isomer thereof;
- or a nontoxic pharmacologically acceptable acid addition salt or ester thereof.
Dependencies are inferred from the claim text.