Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases

A compound of Formula I

• wherein:
• X is N or O;
• Y is NH or CH2;
• R1 and R2 are independently hydrogen, halogen, or C1-C3 alkyl, with the proviso that both R1 and R2 cannot be hydrogen at the same time;
• when X is N then R3 and R4 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, alkoxy, substituted alkoxy, arylalkoxy, or substituted arylalkoxy;
• or R3 and R4 together with X constitute a substituted or unsubstituted heterocyclyl group;
• when X is O then R3 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, alkoxy, substituted alkoxy, arylalkoxy, or substituted arylalkoxy and R4 is absent;
• and
• R5 is hydrogen or halogen;
• or a pharmaceutically acceptable salt, ester, prodrug, or amide thereof.