Compositions of optically pure (+) norcisapride
AssigneeSepracor Inc.
InventorsJohn R. McCullough, Thomas P. Jerussi
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Abstract
Compositions and methods utilizing the optically pure (+) isomer of norcisapride are disclosed. This compound has surprisingly been found to be a potent drug for the treatment of disorders of the central nervous system. The compound, (+) norcisapride, has also been found to be a potent antiemetic agent. Finally, the (+) isomer of norcisapride also avoids certain adverse side effects and certain adverse drug interactions.
Claims9
A pharmaceutical composition suitable for administration to a human which comprises (+) norcisapride or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer;
- and a pharmaceutically acceptable carrier or excipient.
A pharmaceutical composition which comprises (a) a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer;
- and (b) another therapeutic agent.
Dependencies are inferred from the claim text.