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US 6,632,822 B1Granted
Compounds and therapeutic methods
AssigneeThe Australian National University
InventorsRodney W. Rickards, Geoffrey D. Smith, Kiaran Kirk
Life of this patent
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Abstract
The present invention relates to indolo[3,2-j]phenanthridine compounds and their use in the treatment of cancer and other diseases of humans and animals including parasitic diseases such as those of Apicomplexan origin, compositions containing said compounds and methods of treatment using them.
Claims14
A compound of Formula (I):
- wherein
- R is selected from hydrogen, alkyl, acyl, carboxyalkyl, carboalkoxyalkyl;
- m and n are independently selected from 0, 1, 2;
- each Y and each Z are independently selected from halo, acyl, nitro, amino, alkylamino, acylamino, hydroxy, acyloxy, alkoxy, alkyl, CO2H, CO2alkyl, CONX2 (where each X is independently, H or alkyl), SO3H, SO2NX2 (wherein each X is independently H or alkyl), nitrile, formyl, carboxyalkyl, carboalkoxyalkyl;
- a, b, c and d are independently selected from hydrogen, hydroxy, alkoxy, acyloxy, alkyl;
- or,
- a and b together and/or c and d together independently form a carbonyl group (C═O), an imine group (C═N—R1, where R1 is alkyl, hydroxy, alkoxy or amino NR2R3), or an alkene group (C═CR2R3, where R2 and R3 are independently hydrogen or alkyl) wherein the Compound of Formula (I) is as the N-oxide or unoxidized base,
- or salt, derivative or prodrug thereof.
5 more elements
A compound of Formula (II):
- wherein
- R is selected from hydrogen, alkyl, acyl carboxyalkyl, carboalkoxyalkyl;
- in and n are independently selected from 0, 1, 2;
- each Y and each Z are independently selected from halo, acyl, nitro, amino, alkylamino, acylamino, hydroxy, acyloxy, alkoxy, alkyl, CO2H, CO2alkyl, CONX2 (wherein each X is independently selected from hydrogen or alkyl), sulfate, nitrile formyl carboxyalkyl, carboalkoxyalkyl;
- and
- R4 and R5 are independently selected from hydrogen, hydroxy, alkoxy, acyloxy or alkyl, wherein the compound of Formula (II) is as the N-oxide or unoxidized base
- or a salt, derivative or prodrug thereof.
4 more elements
Dependencies are inferred from the claim text.