Inhibitors of factor Xa

A compound of formula (I):

• A—Q—D—G—J—X
• wherein:
• A is phenyl, which is substituted with 0-2 R1 groups;
• each R1 is a member independently selected from the group consisting of:
• halo, —CN, —C(═O)—N(R2, R3), —NO2, —SO2N(R2, R3), —SO2R2, —(CH2)mNR2R3, —(CH2)m—C(═NR3)—R2, —(CH2)m—C(═NR2)—N(R2,R3), —(CH2)m—N(R2)—C(═NR2)—N(R2,R3), —(CH2)mNR2—C3-6heterocyclics, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C0-4alkylC3-8cycloalkyl, —CF3, —OR2, and a 5-6 membered heterocyclic system having from 1-4 hetero atoms each independently selected from the group consisting of N, O and S, wherein from 1-4 hydrogen atoms on the heterocyclic system may be independently replaced with a member selected from the group consisting of halo, C1-C4-alkyl, —CN, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C0-4alkylC3-8cycloalkyl and —NO2;
• each of R2 and R3 is a member independently selected from the group consisting of:
• —H, —C1-6alkyl, —C1-6alkyloxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl, —S(═O)2—OH, —CN, —CF3 and —NO2;
• m is an integer of 0-2;
• Q is a direct link;
• D is phenyl, which is substituted with 0-2 R1a groups;
• each R1a is a member independently selected from the group consisting of:
• halo, —C1-6alkyl, —C1-6alkyloxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl, —S(═O)2—OH, —CN, —NO2, —(CH2)n—N(—R2a, —R3a), —S(═O)2—N(—R2a, —R3a), —S(═O)2R2a, —CF3, —(CH2)n—OR2a, —C(═O)—O—R2a, —C(═O)—N(—R2a, —R3a), —C(═NH)—N(—R2a, —R3a), —C(═NMe)—N(—R22, —R3a), 2-imidazolin-2-yl, 1-methyl-2-imidazolin-2-yl and a 5-6 membered aromatic heterocyclic ring having 1-4 heteroatoms each independently selected from the group consisting of N, O and S and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the aromatic heterocyclic ring and the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl, —CN, —CF3 and —NO2;
• n is an integer of 0-2;
• each of R2a and R3a is a member independently selected from the group consisting of:
• —H, —C1-6alkyl, —C1-6alkyloxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl, —S(═O)2—OH, —CN, —CF3 and —NO2;
• E is —NH—C(═O)—;
• G is a pyrazolyl, which is substituted with 0-2 R1b groups;
• each R1b is a member independently selected from the group consisting of:
• halo, —C1-6alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl, —C1-4alkyl-C(═O)—OH, —CN, —NO2, —S(═O)2—OH, —N(—R2b, —R3b), —C(═O)—N(—R2b, —R3b), —S(═O)2—N(—R2b, —R3b), —S(═O)2—R2b, —CF3, —O—R2b, —O—CH2—CH2—O—R2b, —O—CH2—C(═O)—O—R2b, —N(—R2b)—CH2—CH2—O—R2b, —N(—CH2—CH2—O—R2b)2, —N(—R2b)—C(═O)—R3b, —N(—R2b)—S(═O)2—R3b, and 5-6 membered heterocyclic ring having 1-4 hetero atoms each independently selected from the group consisting of N, O and S, substituted with 0-4 R1b′ groups;
• each of R2b and R3b is a member independently selected from the group consisting of:
• —H, —C1-6alkyl, —C1-6alkyloxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl, —S(═O)2—O−, —CN, —CF3 and —NO2;
• each R1b′ is a member independently selected from the group consisting of:
• halo, —C1-6alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl, —C1-4alkyl-C(═O)—OH, —CN, —NO2, —S (═O)2—OH, —N(—R2b′, —R3b′), —C(═O)—N(—R2b′, —R3b′), —S(═O)2—N(R2b′, —R3b′) —S(═O)2—R2b′,—CF3, —O—R2b′, —O—CH2—CH2—O—R2b′, —O—CH2—C(═O)—O—R2b′, —N(—R2b′)—CH2—CH2—O—R2b′, —N(—CH2—CH2—O—R2b′)2, —N(—R2b′)—C(═O)—R3b′ and —N(—R2b′)—S(═O)2—R3b′;
• each of R2b′ and R3b′ is a member independently selected from the group consisting of:
• —H, —C1-6alkyl, —C1-6alkoxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloakyl, —C0-4alkylC3-8cycloalkyl, —S(═O)2—OH, —CN, —CF3 and —NO2;
• J is a direct link
• X is a naphthyl, which is substituted with 0-3 R1c groups;
• each R1c is a member independently selected from the group consisting of:
• halo, —CF3, —C1-6alkyl, —C2-6alkenyl, —C2-6alkynyl, —C0-6alkylC3-8cycloalkyl, —C1-4alkyl-C(═O)—OH, —CF3, —CN, —NO2, —N(—R2c, —R3c), —C(═O)—N(—R2c, —R3c), —C(═NH)—N(—R2c, —R3c), —C(═NMe)—N(—R2c, —R3c), —S(═O)2—N(—R2c,—R3c), —S(═O)2—R2c, —S(═O)2—OH, —O—R2c, —O(—CH2)z—O—R2c, —O(—CH2) z—C(═O)—O—R2c, —O(—CH2)z—O—R2c, —N[(—CH2)z—O—R2c]2, —(CH2)z—N(—R2c)—C(═O)—R3c, —(CH2)z—N(—R2c)—S(═O)2—R3c, and a 5-6 membered heterocyclic ring having 1-4 heteroatoms each independently selected from the group consisting of N, O and S;
• z is an integer of 0-4;
• each of R2c and R3c is a member independently selected from the group consisting of:
• —H, —C1-6alkyl, —C1-6alkyloxy, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-6alkylC3-8cycloalkyl and —C0-6alkyl-(carbocyclic aryl), wherein from 0-4 hydrogen atoms on the ring atoms of the carbocyclic aryl moiety may be independently replaced with a member selected from the group consisting of halo, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl, —S(═O)2—OH, —CN, —CF3 and —NO2;
• or all pharmaceutically acceptable diastereomers, enantiomers or mixtures thereof, salts, hydrates or solvates thereof.