(2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5- tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakashi Sohda, Shigehisa Taketomi, Tsuneo Oda
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Abstract
This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.
Claims8
A pharmaceutical composition comprising optically pure (2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide and a pharmaceutically acceptable carrier.
A method of promoting osteogenesis in a mammal which comprises administering to said mammal in need thereof a therapeutically effective amount of optically pure (2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide.
A method of preventing or treating bone diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of optically pure (2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide.
A method of promoting cure of bone fracture in a mammal in need thereof which comprises administering to said mammal a therapeutically effective amount of optically pure (2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide.
Dependencies are inferred from the claim text.