Neurologically-active compounds
AssigneesThe University of Sydney, Polychip Pharmaceuticals Pty Ltd
InventorsGraham A. R. Johnston, Peter M. Burden, Kenneth Noel Mewett, Mary Chebib
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Abstract
The invention provides methods for enhancing cognitive activity and stimulating memory capacity, comprising the step of administering an effective amount of a compound with GABAC receptor antagonist activity to an animal in need of such treatment. Preferably the compound has selective GABAc receptor antagonist activity, and more preferably comprises a phosphinic acid group. The invention also provides novel compounds and compositions. The methods of the invention are useful in the treatment of dementias and conditions involving cognitive deficit, or memory impairment.
Claims16
A method of enhancing cognitive activity in an animal, comprising administering to an animal in need of such treatment an effective amount of a compound that has GABAC receptor antagonist activity and selectivity for the rho-2 subtype of GABAC receptors, the compound having formula I or formula II:
- wherein X represents hydrogen, an alkyl group, an alkyl group substituted with a halogen, or a hydroxyalkyl group, and
- Y represents hydrogen, a halogen, an alkyl, alkenyl, alkynyl, alkoxy or acyl group, or an alkyl, alkenyl, alkynyl, alkoxy or acyl group that is substituted with halogen, nitrile, or NO2.
Dependencies are inferred from the claim text.