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US 6,632,790 B1Granted
Laminin 2 and methods for its use
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorPeter Yurchenco
Life of this patent
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Abstract
The present invention provides substantially purified laminin 2, methods for making recombinant laminin 2, cells that express recombinant laminin 2, and methods for using the substantially purified laminin 2 to accelerate peripheral nervous system nerve regeneration, and to promote cell attachment and migration.
Claims8
A substantially purified laminin α2 chain polypeptide comprising the amino acid sequence shown in SEQ ID NO:2, or a secreted form thereof.
Substantially purified laminin 2 comprising:
- (a) a laminin α2 chain polypeptide comprising the amino acid sequence shown in SEQ ID NO:2 or a secreted form thereof;
- (b) a laminin β1 chain polypeptide comprising an amino acid sequence that shares at least 70 percent identity to an amino acid sequence of one or more of SEQ ID NO:14, and 16, or a secreted form thereof;
- and
- (c) a laminin γ1 chain polypeptide comprising an amino acid sequence that shares at least 70 percent identity to an amino acid sequence of one or more of SEQ ID NO:22, 24, 26, and 28, or a secreted form thereof;
- wherein the substantially purified laminin 2 supports adhesion of C2C12 myoblasts.
2 more elements
Dependencies are inferred from the claim text.