DNA immunization against chlamydia infection
AssigneeAventis Pasteur Limited
InventorRobert C. Brunham
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Abstract
Nucleic acid, including DNA, immunization is used to generate a protective immune response in a host, including humans, to a serine-threonine kinase (STK) of a strain of Chlamydia. A non-replicating vector, including a plasmid vector, contains a nucleotide sequence encoding a STK or a fragment of the STK that generates antibodies that specifically react with STK and a promoter sequence operatively coupled co the first nucleotide sequence for expression of the STK in the host. The non-replicating vector may be formulated with a pharmaceutically-acceptable carrier for in vivo administration to the host.
Claims1
A pcDNA3 plasmid vector comprising:
- a nucleotide sequence encoding a serine-threonine kinase (STK) of a strain of Chlamydia trachomatis, and consisting of SEQ ID No:
- 1, and
- a promoter sequence operatively coupled to said nucleotide sequence for expression of said STK in a host to which the vector is administered, said promoter sequence being the human cytomegalovirus major intermediate-early promoter-enhancer region.
Dependencies are inferred from the claim text.