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US 6,632,640 B1Granted
Vaccine against Staphylococcus intoxication
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsJohn S. Lee, Peter Pushko, Jonathan F. Smith, Robert G. Ulrich
Life of this patent
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Abstract
Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
Claims9
A recombinant DNA construct comprising:
- (i) a VEE virus replicon vector which contains
- (ii) an isolated nucleic acid fragment comprising the nucleic acid sequence encoding mSEA, which sequence expresses a peptide product that does not bind to MHC on T-cells.
A recombinant DNA construct comprising:
- (i) a VEE virus replicon vector which contains
- (ii) an isolated nucleic acid fragment comprising the nucleic acid sequence encoding mSEA SEQ ID NO:1.
Dependencies are inferred from the claim text.