Glutamine: fructose-6-phosphate amidotransferase, its production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsKazunori Nishi, Yukiko Hikichi, Yasushi Shintani
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AssigneeTakeda Chemical Industries, Ltd.
InventorsKazunori Nishi, Yukiko Hikichi, Yasushi Shintani
Estimating the term…
This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.
A method for screening for a compound, or a salt thereof, which promotes or inhibits the enzyme activity of a protein having an amino acid sequence represented by SEQ ID NO:1 or a salt thereof, the method comprising measuring and comparing the enzyme activity of the protein, a partial peptide of the protein, or a salt thereof, wherein said partial peptide, or salt thereof, has the activity of a glutamine:fructose-6-phosphate amidotransferase, in cases that (i) a substrate is contacted with the protein, partial peptide or a salt thereof and (ii) the substrate and a test compound are contacted with the protein, the partial peptide or a salt thereof.
A method for screening for a compound which promotes or inhibits the enzyme activity of glutamine:fructose-6-phosphate amidotransferase, the method comprising
Dependencies are inferred from the claim text.