Loading patent…
AssigneePresident and Fellows of Harvard College
InventorsLaurie H. Glimcher, Andreas M. Reimold
Estimating the term…
The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of hepatocyte growth, plasma cell differentiation and/or T cell subset activity, using XBP-1-containing indicator compositions or XBP-1-deficient cells, are provided. Methods of modulating hepatocyte growth, plasma cell differentiation and/or T cell subset activity (e.g., Th2 cytokine production) using agents that modulate the activity of XBP-1 are also provided. Methods for diagnosing disorders associated with aberrant hepatocyte growth, plasma cell differentiation and/or T cell subset activity, by assessing a change in XBP-1 expression, are also provided. XBP-1 deficient cells, animals and embryos, as well as kits for the methods of the invention, are also provided by the invention.
A method of identifying a compound that modulates hepatocyte cell growth comprising
A method of identifying a compound that modulates plasma cell differentiation comprising
A method of identifying a compound that modulates TH2 cell subset activity comprising:
Dependencies are inferred from the claim text.