Composite hydrogel drug delivery systems
AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
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Abstract
Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
Claims28
A drug delivery system comprising:
- a continuous hydrogel matrix, wherein the hydrogel matrix is formed by chemical reaction of macromers;
- a hydrophobic phase dispersed within the continuous hydrogel matrix;
- and
- a therapeutic agent dispersed within the hydrophobic phase, the hydrophobic phase controlling a rate of release of the therapeutic agent from the hydrogel matrix.
A drug delivery system comprising:
- a continuous hydrogel matrix, wherein the hydrogel matrix is formed by chemical reaction of macromers;
- a hydrophobic microdomain dispersed within the continuous hydrogel matrix;
- and
- a therapeutic agent dispersed within the hydrophobic microdomain, the hydrophobic microdomain controlling a rate of release of the therapeutic agent from the hydrogel matrix.
A drug delivery system comprising:
- a biodegradable hydrogel matrix, wherein the biodegradable hydrogel matrix is formed by chemical reaction of macromers;
- a hydrophobic microdomain dispersed within the hydrogel matrix, the microdomain comprising a compound immiscible with water;
- and
- a therapeutic agent dissolved or suspended in the microdomain, the agent having a molecular weight of less than 100,000.
Dependencies are inferred from the claim text.