Vaccine compositions and method of modulating immune responses
AssigneeGenitrix, LLC
InventorAndrew Segal
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Abstract
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an antigen with an APC binding domain of an opsonin forms a molecule, that is, a fusion polypeptide, which when administered to a subject modulates an immune response to the antigen.
Claims6
A method of modulating in a human subject an immune response to an antigen, comprising administering to the subject a nucleic acid molecule encoding a polypeptide comprising said antigen, a secretory sequence, and an amino acid sequence that binds to a cell surface molecule of an antigen presenting cell, wherein said antigen presenting cell is a dendritic cell in an amount effective to modulate an immune response.
Dependencies are inferred from the claim text.