Leptospiral major outer membrane protein, LipL 32
AssigneeThe Regents of the University of California
InventorDavid A. Haake
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Abstract
An antigenic preparation is provided containing an outer membrane protein associated with pathogenic strains of Leptospira. The protein has been designated ALipL32″ for Alipoprotein from Leptospira≅ and because the isolated polypeptide migrates to a position corresponding to a molecular weight of 32 kD in a denaturing polyacrylamide gel. The invention provides polynucleotides encoding LipL32 and antibodies that bind the protein which are useful in the diagnosis of leptospirosis. In addition, LipL32 can be used immunologically as a vaccine for spirochete-associated pathologies.
Claims8
A purified LipL32 polypeptide having an amino acid sequence as set forth in SEQ ID NO:2, or peptide thereof comprising amino acid residues 20 to 272 of SEQ ID NO:2.
An immunogenic composition useful for inducing an immune response to a pathogenic spirochete in a subject, comprising an immunogenically effective amount of a LipL32 polypeptide comprising SEQ ID NO:2, or peptide thereof comprising amino acid residues 20 to 272 of SEQ ID NO:2, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.