Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same
AssigneeNew York University
InventorXue-Ru Wu
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Abstract
The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli and an immunizing composition containing such an anti-idiotypic antibody or antigen-binding fragment thereof as an active immunizing component. The present invention also relates to a method for stimulating and enhancing the production of antibodies which recognize and bind to FimH of uropathogenic Type-I-fimbriated Escherichia coli, but not to FimH of non-uropathogenic Type I-fimbriated Escherichia coli.
Claims4
A monoclonal anti-idiotypic antibody or antigen-binding fragment thereof which immunospecifically binds to an idiotype of a second antibody, wherein said idiotype of said second antibody specifically binds an epitope of FimH adhesin from uropathogenic Type I-fimbriated Escherichia coil which is not present in FimH adhesin from non-uropathogenic Type I-fimbriated Escherichia coli.
Dependencies are inferred from the claim text.