US 6,632,428 B1 · Methods and compositions employing red rice fermentation products

Abstract

Methods and compositions are disclosed which comprise red rice fermentation products, that can be used as natural dietary supplements and/or medicaments for the treatment or prevention of hyperlipidemia and associated disorders and symptoms, such as cardiovascular diseases, cerebrovascular diseases, diabetes, hypertension, obesity, asthenic breathing, chronic headache, chest pain and tightness, limb swelling and distention, loss of appetite and excess expectoration. The methods and compositions are effective in lowering both the serum cholesterol and serum triglyceride levels in humans, and can be used for maintaining cardiovascular health. The invention also encompasses particular Monascus strains that yield fermentation products with the desired biological activities.

Claims3

Dependent claims

A composition for treating elevated above normal serum cholesterol and/or triglycerides, said composition comprising:

a solid, impure residue separated from the fermentation broth of fermentation of the strain or mixtures of a strain of Monascus, said residue containing at least about 0.05% lovastatin by weight, and a pharmaceutically acceptable carrier, wherein said Monascus strain comprises a strain selected from the group consisting of Monascus albidus Sato AS 3.570, AS 3.4440, CGMCC No. 0317;
Monascus pilosus Sato AS 3.4444, AS 3.4633, AS 3.4646, AS 3.4647;
Monascus pubigerus Sato AS 3.4445, Monascus ruber van Tieghem AS 3.549, CGMCC No. 0315, CGMCC No. 0316;
Monascus paxii Lingelsheim AS 3.4453;
Monascus fuliginosus Sato AS 3.569, AS 3.1098, AS 3.2091, AS 3.2093, AS 3.2134, IFFI 05035, and Monascus purpureus Went CGMCC No. 0272.

2 more elements

Dependencies are inferred from the claim text.

Methods and compositions employing red rice fermentation products

Life of this patent

Methods and compositions employing red rice fermentation products

Life of this patent

Abstract

Claims3