Human FLTS3 ligand
AssigneeImmunex Corporation
InventorsStewart D. Lyman, Patricia M. Beckmann
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Abstract
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.
Claims22
An isolated polypeptide capable of binding flt3, wherein said polypeptide is encoded by the cDNA insert of huflt3/flk-2L (#9-2) in E. coli DH10α having ATCC Accession No. 69382.
An isolated polypeptide capable of binding flt3, wherein said polypeptide comprises amino acids 28-160 of SEQ ID NO:6.
An isolated polypeptide capable of binding flt3, wherein said polypeptide comprises an amino acid sequence which is at least 80% identical to amino acids 28-160 of SEQ ID NO:6.
An isolated polypeptide comprising a fragment of amino acids 28-182 of SEQ ID NO:6, wherein said fragment is capable of binding flt3.
An isolated polypeptide comprising a fragment of amino acids 28-160 of SEQ ID NO:6, wherein said fragment is capable of binding flt3.
Dependencies are inferred from the claim text.