Viscoelastics for use in middle ear surgery
AssigneeAlcon Inc.
InventorsMasoud R. Jafari, Uday Doshi
Life of this patent
Estimating the term…
Abstract
Disclosed are viscoelastic compositions and methods of their use in surgical and non-surgical packing and in effecting drug delivery, especially in conjunction with trauma to of disorders of the ear.
Claims18
A method of inhibiting or reducing fibrosis and/or adhesion in traumatized tissues, comprising the administration of a tissue stabilizing effective amount of a viscoelastic agent to the traumatized tissue, wherein said agent is characterized by a viscosity (V0) of at least 30 Pa.s, and a cohesion-dispersion index (CDI) greater than zero and less than 20, such that the product of said viscosity and cohesion dispersion index afford a retention factor (R) of at least 600 in accordance with the formula:
- V0×CDI×R;
- and wherein the viscoelastic agent comprises a polymer or polymers selected from the group consisting of:
- modified or unmodified sodium hyaluronate, chondroitin sulfate, polyacrylamide carbomers, hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone, proteoglycans, collagen, methylcellulose, carboxymethyl cellulose, ethylcellulose, keratin, and combinations thereof.
A composition for use in stabilizing delicate tissue, comprising a viscoelastic agent, said viscoelastic agent having a retention ratio (R) greater than 600, a viscosity (V0) of at least 30 Pa.s, and a cohesion-dispersion index (CDI) greater than zero and less than 20, in accordance with the formula:
- V0×CDI=R;
- wherein the viscoelastic agent is selected from the group consisting of:
- modified or unmodified sodium hyaluronate, chondroitin sulfate, polyacrylamide, carbomers, hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone, proteoglycans, collagen, methylcellulose, carboxymethyl cellulose, ethylcellulose, keratin, and combinations thereof.
A composition for delivery of a therapeutic agent, comprising a therapeutically effective amount of the therapeutic agent, and a viscoelastic agent, wherein the viscoelastic agent is selected from the group consisting of:
- modified or unmodified sodium hyaluronate, chondroitin sulfate, polyacrylamide, carbomers, hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone, proteoglycans, collagen, methylcellulose, carboxymethyl cellulose, ethylcellulose, keratin, and combinations thereof, said viscoelastic agent, having a retention ratio greater than 600, a viscosity of at least 30 Pa.s, and a cohesion-dispersion (CDI) greater than zero and less than 20, in accordance with the formula:
- V0×CDI=R;
- together with a pharmaceutically acceptable vehicle therefor.
Dependencies are inferred from the claim text.