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US 6,632,359 B1Granted
Blood purifying apparatus
AssigneeAsahi Medical Co., Ltd.
InventorsSatoshi Uezumi, Makoto Yoshida
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AssigneeAsahi Medical Co., Ltd.
InventorsSatoshi Uezumi, Makoto Yoshida
Estimating the term…
A blood purifying apparatus having excellent purification performance (elimination of low molecular proteins, etc.) and being contaminated with little endotoxins flowing from the dialyzate side is described. Attention was paid to the solute permeability coefficient α and water permeability performance Lp of blood purifying apparatus and the relation between α and Lp has been examined. As a result, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the value α/Lp to 6×10−7 or above, or regulating α within a range of 8×105 to 1.5×10−3, and the value α×Lp to 2.4×10−2 or less. Also, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the invasion ratio which is obtained by the polymer invasion test to 10% or less.
A blood purifying apparatus wherein a ratio α/Lp is in a range of 6×10−7 to 3×10−5, said value obtained by a solute permeability coefficient α(Hr·m2/ml), which is obtained by a penetration test of a high molecular weight substance, being divided by water permeability performance Lp (ml/Hr/mmHg/m2) which is in a range of 50 to 170.
A blood purifying apparatus wherein a solute permeability coefficient o(Hr·m2/ml), which is obtained by a penetration test of a high molecular weight substance, is in a range of 8×10−5 to 1.5×10−3, and the product of the solute permeability coefficient α and the water permeability performance Lp (ml/Hr/mmHg/m2), which is obtained by said test, is in the range of more than 0 to 2.4×10−2.
A blood purifying apparatus in which an invasion ratio is obtained by an invasion test of a high molecular weight substance in a range of 0% to 10%.
Dependencies are inferred from the claim text.