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US 6,630,617 B1Granted
Enzymes involved in squalene metabolism
AssigneeE. I. Du Pont de Nemours and Company
InventorsOmolayo O. Famodu, Anthony J. Kinney, J. Antoni Rafalski
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Abstract
This invention relates to an isolated nucleic acid fragment encoding a squalene metabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the squalene metabolic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the squalene metabolic enzyme in a transformed host cell.
Claims13
An isolated polynucleotide comprising:
- (a) a nucleotide sequence encoding a polypeptide having squalene monooxygenase activity, wherein the amino acid sequence of the polypeptide and the amino acid sequence of SEQ ID NO:14 have at least 90% identity based on the Clustal method of alignment, or
- (b) the complement of the nucleotide sequence, wherein the complement and the nucleotide sequence contain the same number of nucleotides and are 100% complementary.
Dependencies are inferred from the claim text.