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US 6,630,609 B2Granted
Taxane synthesis method and intermediates
AssigneeFlorida State University
InventorsRobert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
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Abstract
A process for the preparation of a composition having the formula: in which a compound having the formula: is treated with a base and a silylating agent.
Claims5
A process for the preparation of a compound having the formula:
- the process comprising treating a compound having the formula:
- with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxy protecting group.
A compound selected from the group consisting of:
- wherein P2, P7, P9, P10 and P13 are independently selected from hydrogen and hydroxy protecting group.
Dependencies are inferred from the claim text.